![]() ![]() At the molecular level, it has been observed that it mediates cell proliferation inhibition and apoptosis in insects 6 and upregulates the genes involved in juvenile hormone synthesis in spiders 5. However, it has also been observed in other arthropods 3, 4, 5. It regulates insect growth by mimicking the juvenile hormone, preventing the insect from reaching maturity 2. 7) is a carbamate used to control various insect pests in crops and ornamental cultures 1. The pesticide Fenoxycarb (IUPAC: ethyl carbamate, CAS No. Therefore, additional research is required to confirm the safety of Fenoxycarb in non-arthropod species in the long term. However, Aplysianin-A, a gene related to immunity, was altered so the long-term effect could be relevant. acuta in the tested time and concentrations. From the results, it can be concluded that Fenoxycarb shows a weak response at the molecular level in P. Three of the genes, AchE, HSP17.9, and ApA, showed responses to the presence of Fenoxycarb at 1 μg/L, with no statistically significant responses in the rest of the genes and at the remaining concentrations. Forty genes related to the endocrine system, the DNA repair mechanisms, the detoxification mechanisms, oxidative stress, the stress response, the nervous system, hypoxia, energy metabolism, the immune system, and apoptosis were analyzed. For 1 week, animals were exposed to 0.01, 1, and 100 μg/L and the RNA was isolated to analyze the gene expression by retrotranscription and Real-Time PCR. This article analyzes the impact of Fenoxycarb, an analog of JH, on Physella acuta, an aquatic gastropod. However, the lack of effect on non-target species requires confirmation. Analogs of the juvenile hormone (JH) interfere endocrine system of arthropods. ![]() The search for new pest control methods has focused on compounds with low or no toxic effects in non-target organisms. Gene expression response of the non-target gastropod Physella acuta to Fenoxycarb, a juvenile hormone analog pesticide
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